N. Dzamko : rechercher sur Z-Library

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1

DNA extraction from fresh-frozen and formalin-fixed, paraffinembedded human brain tissue

Wang, Jian-Hua, Gouda-Vossos, Amany, Dzamko, Nicolas, Halliday, Glenda, Huang, Yue

Journal:

Neuroscience Bulletin

Année:

2013

Langue:

english

Fichier:

PDF, 644 KB

english, 2013

2

Parkinson’s progression prediction using machine learning and serum cytokines

Ahmadi Rastegar, Diba, Ho, Nicholas, Halliday, Glenda M., Dzamko, Nicolas

Journal:

npj Parkinson s Disease

Année:

2019

Fichier:

PDF, 859 KB

2019

3

Leucine Rich Repeat Kinase 2 and Innate Immunity

Ahmadi Rastegar, Diba, Dzamko, Nicolas

Journal:

Frontiers in Neuroscience

Année:

2020

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2020

4

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity

Nirupa Sachithanandan, Barbara C. Fam, Stacey Fynch, Nicolas Dzamko, Matthew J. Watt, Sam Wormald, Jane Honeyman, Sandra Galic, Joseph Proietto, Sofianos Andrikopoulos, Andrea L. Hevener, Thomas W.H.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 460 KB

english, 2010

5

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin

J.-M. Ye, N. Dzamko, M. E. Cleasby, B. D. Hegarty, S. M. Furler, G. J. Cooney, E. W. Kraegen

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 233 KB

english, 2004

6

AMPK-dependent hormonal regulation of whole-body energy metabolism

N. L. Dzamko, G. R. Steinberg

Journal:

Acta Physiologica

Année:

2009

Langue:

english

Fichier:

PDF, 245 KB

english, 2009

7

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, Xianming, Dzamko, Nicolas, Prescott, Alan, Davies, Paul, Liu, Qingsong, Yang, Qingkai, Lee, Jiing-Dwan, Patricelli, Matthew P, Nomanbhoy, Tyzoon K, Alessi, Dario R

Journal:

Nature Chemical Biology

Année:

2011

Langue:

english

Fichier:

PDF, 431 KB

english, 2011

8

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

Watt, Matthew J, Dzamko, Nicolas, Thomas, Walter G, Rose-John, Stefan, Ernst, Matthias, Carling, David, Kemp, Bruce E, Febbraio, Mark A, Steinberg, Gregory R

Journal:

Nature Medicine

Année:

2006

Langue:

english

Fichier:

PDF, 279 KB

english, 2006

9

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation

Nicolas Dzamko, Jonathan D. Schertzer, James G. Ryall, Rohan Steel, S. Lance Macaulay, Sheena Wee, Zhi-Ping Chen, Belinda J. Michell, Jonathan S. Oakhill, Matthew J. Watt, Sebastian Beck Jørgensen, Go

Journal:

The Journal of Physiology

Année:

2008

Langue:

english

Fichier:

PDF, 378 KB

english, 2008

10

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

Nichols, R. Jeremy, Dzamko, Nicolas, Hutti, Jessica E., Cantley, Lewis C., Deak, Maria, Moran, Jennifer, Bamborough, Paul, Reith, Alastair D., Alessi, Dario R.

Journal:

Biochemical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 1.56 MB

english, 2009

11

Unlocking the secrets of LRRK2 function with selective kinase inhibitors

Dzamko, Nicolas, Halliday, Glenda M

Journal:

Future Neurology

Année:

2013

Langue:

english

Fichier:

PDF, 606 KB

english, 2013

12

An emerging role for LRRK2 in the immune system

Dzamko, Nicolas, Halliday, Glenda M.

Journal:

Biochemical Society Transactions

Année:

2012

Langue:

english

Fichier:

PDF, 283 KB

english, 2012

13

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Deng, Xianming, Elkins, Jonathan M., Zhang, Jinwei, Yang, Qingkai, Erazo, Tatiana, Gomez, Nestor, Choi, Hwan Geun, Wang, Jinhua, Dzamko, Nicolas, Lee, Jiing-Dwan, Sim, Taebo, Kim, NamDoo, Alessi, Dari

Journal:

European Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2013

14

Inflammation is genetically implicated in Parkinson’s disease

Dzamko, N., Geczy, C.L, Halliday, G.M

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 882 KB

english, 2014

15

Whole Body Deletion of AMP-activated Protein Kinase 2 Reduces Muscle AMPK Activity and Exercise Capacity

Steinberg, G. R., O'Neill, H. M., Dzamko, N. L., Galic, S., Naim, T., Koopman, R., Jorgensen, S. B., Honeyman, J., Hewitt, K., Chen, Z.-P., Schertzer, J. D., Scott, J. W., Koentgen, F., Lynch, G. S.,

Journal:

Journal of Biological Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 2.34 MB

english, 2010

16

Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase-Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat-Fed Rats

Ye, J.-M., Dzamko, N., Hoy, A. J., Iglesias, M. A., Kemp, B., Kraegen, E.

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 193 KB

english, 2006

17

Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms

Cleasby, M. E., Dzamko, N., Hegarty, B. D., Cooney, G. J., Kraegen, E. W., Ye, J.-M.

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 349 KB

english, 2004

18

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Dzamko, Nicolas, van Denderen, Bryce J. W., Hevener, Andrea L., Jørgensen, Sebastian Beck, Honeyman, Jane, Galic, Sandra, Chen, Zhi-Ping, Watt, Matthew J., Campbell, Duncan J., Steinberg, Gregory R.,

Journal:

Journal of Biological Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2010

19

Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation

Munoz, Lenka, Kavanagh, Madeline E., Phoa, Athena F., Heng, Benjamin, Dzamko, Nicolas, Chen, Ew-Jun, Doddareddy, Munikumar Reddy, Guillemin, Gilles J., Kassiou, Michael

Journal:

European Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2015

20

Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity

Spargo, F. J., McGee, S. L., Dzamko, N., Watt, M. J., Kemp, B. E., Britton, S. L., Koch, L. G., Hargreaves, M., Hawley, J. A.

Journal:

AJP Endocrinology and Metabolism

Année:

2007

Langue:

english

Fichier:

PDF, 148 KB

english, 2007

21

Prior Thiazolidinedione Treatment Preserves Insulin Sensitivity in Normal Rats during Acute Fatty Acid Elevation: Role of the Liver

Ye, Ji-Ming, Frangioudakis, Georgia, Iglesias, Miguel A., Furler, Stuart M., Ellis, Bronwyn, Dzamko, Nicholas, Cooney, Gregory J., Kraegen, Edward W.

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 362 KB

english, 2002

22

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

Nichols, R. Jeremy, Dzamko, Nicolas, Morrice, Nicholas A., Campbell, David G., Deak, Maria, Ordureau, Alban, Macartney, Thomas, Tong, Youren, Shen, Jie, Prescott, Alan R., Alessi, Dario R.

Journal:

Biochemical Journal

Année:

2010

Langue:

english

Fichier:

PDF, 2.07 MB

english, 2010

23

Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent

Jeppesen, J., Albers, P. H., Rose, A. J., Birk, J. B., Schjerling, P., Dzamko, N., Steinberg, G. R., Kiens, B.

Journal:

The Journal of Lipid Research

Année:

2011

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2011

24

Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers

Dzamko, Nicolas, Rowe, Dominic B., Halliday, Glenda M.

Journal:

Movement Disorders

Année:

2016

Langue:

english

Fichier:

PDF, 659 KB

english, 2016

25

LRRK2 mutations, regulation and 14–3–3 protein interaction: implications for Parkinson’s disease

Dzamko, Nicolas, Alessi, Dario R

Journal:

Future Neurology

Année:

2011

Langue:

english

Fichier:

PDF, 402 KB

english, 2011

26

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser 910 /Ser 935 , disruption of 14-3-3 binding and altered cytoplasmic localization

Dzamko, Nicolas, Deak, Maria, Hentati, Faycal, Reith, Alastair D., Prescott, Alan R., Alessi, Dario R., Nichols, R. Jeremy

Journal:

Biochemical Journal

Année:

2010

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2010

27

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

Dzamko, Nicolas, Gysbers, Amanda, Perera, Gayathri, Bahar, Anita, Shankar, Amrita, Gao, Jianqun, Fu, YuHong, Halliday, Glenda M.

Journal:

Acta Neuropathologica

Année:

2017

Langue:

english

Fichier:

PDF, 3.12 MB

english, 2017

28

LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies

Dzamko, Nicolas, Gysbers, Amanda M., Bandopadhyay, Rina, Bolliger, Marc F., Uchino, Akiko, Zhao, Ye, Takao, Masaki, Wauters, Sandrine, van de Berg, Wilma D. J., Takahashi-Fujigasaki, Junko, Nichols, R

Journal:

Movement Disorders

Année:

2016

Langue:

english

Fichier:

PDF, 694 KB

english, 2016

29

Inhibitor treatment of peripheral mononuclear cells from Parkinson’s disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker

Perera, G., Ranola, M., Rowe, D. B., Halliday, G. M., Dzamko, N.

Journal:

Scientific Reports

Année:

2016

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2016

30

Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers

Zhao, Ye, Perera, Gayathri, Takahashi-Fujigasaki, Junko, Mash, Deborah C, Vonsattel, Jean Paul G, Uchino, Akiko, Hasegawa, Kazuko, Nichols, R Jeremy, Holton, Janice L, Murayama, Shigeo, Dzamko, Nicola

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 847 KB

english, 2017

31

Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease

Matrone, Carmela, Dzamko, Nicolas, Madsen, Peder, Nyegaard, Mette, Pohlmann, Regina, Søndergaard, Rikke V., Lassen, Louise B., Andresen, Thomas L., Halliday, Glenda M., Jensen, Poul Henning, Nielsen,

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 8.45 MB

english, 2016

32

Parkinsonâ€™s disease-implicated kinases in the brain; insights into disease pathogenesis

Dzamko, Nicolas, Zhou, Jinxia, Huang, Yue, Halliday, Glenda M.

Journal:

Frontiers in Molecular Neuroscience

Année:

2014

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2014

33

LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives

Atashrazm, Farzaneh, Dzamko, Nicolas

Journal:

Clinical Pharmacology Advances and Applications

Année:

2016

Langue:

english

Fichier:

PDF, 763 KB

english, 2016

34

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice

Zhao, Ye, Keshiya, Shikara, Atashrazm, Farzaneh, Gao, Jianqun, Ittner, Lars M., Alessi, Dario R., Halliday, Glenda M., Fu, Yuhong, Dzamko, Nicolas

Journal:

Neurobiology of Disease

Année:

2018

Langue:

english

Fichier:

PDF, 3.77 MB

english, 2018

35

Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease

Atashrazm, Farzaneh, Hammond, Deborah, Perera, Gayathri, Dobson-Stone, Carol, Mueller, Nicole, Pickford, Russell, Kim, Woojin Scott, Kwok, John B., Lewis, Simon J. G., Halliday, Glenda M., Dzamko, Nic

Journal:

Scientific Reports

Année:

2018

Langue:

english

Fichier:

PDF, 3.31 MB

english, 2018

36

LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients

Atashrazm, Farzaneh, Hammond, Deborah, Perera, Gayathri, Bolliger, Marc F., Matar, Elie, Halliday, Glenda M., Schüle, Birgitt, Lewis, Simon J.G., Nichols, R. Jeremy, Dzamko, Nicolas

Journal:

Movement Disorders

Année:

2018

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2018

37

Recent Developments in LRRK2-Targeted Therapy for Parkinson’s Disease

Zhao, Ye, Dzamko, Nicolas

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2019

38

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

Gao, Jianqun, Perera, Gayathri, Bhadbhade, Megha, Halliday, Glenda M., Dzamko, Nicolas

Journal:

Journal of Biological Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2019

39

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

Gao, Jianqun, Perera, Gayathri, Bhadbhade, Megha, Halliday, Glenda M., Dzamko, Nicolas

Journal:

Journal of Biological Chemistry

Année:

2019

Fichier:

PDF, 1.00 MB

2019

40

LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation

Zhao, Ye, Keshiya, Shikara, Perera, Gayathri, Schramko, Lauren, Halliday, Glenda M., Dzamko, Nicolas

Journal:

Neurobiology of Disease

Année:

2020

Fichier:

PDF, 4.59 MB

2020